Urinary organic acid analysis in non-ketotic hyperglycinemia: non-specific occurrence of free benzoic acid, due to a beta-streptococcus infection.

Abstract

The presence of free benzoic acid in the urine of a patient with non-ketotic hyperglycinemia was demonstrated to be due to a urinary tract infection with beta-streptococci (group B), and was eliminated by treatment with Penicillin G. In addition, the continuous excretion of p-hydroxyphenylacetic acid was observed. The patient was also found to excrete small and variable amounts of tiglic acid during the period of observation. Except for benzoic acid, large excesses of any specific organic acid were not observed.

• Authors: R L Geison, B O Rowley, T Gerritsen
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 60 Issue 2 Pg. 137-42 (Apr 16 1975) ISSN: 0009-8981 [Print] Netherlands
• PMID: 1126035 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzoates
• Carboxylic Acids
• Glycine

Topics

• Adolescent
• Amino Acid Metabolism, Inborn Errors (complications, urine)
• Benzoates (urine)
• Carboxylic Acids (urine)
• Chromatography, Gas
• Glycine (metabolism)
• Humans
• Male
• Streptococcal Infections (complications, urine)
• Time Factors
• Urinary Tract Infections (complications, urine)