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The retinoblastoma family member, p107, is active in non-dividing monocyte-derived dendritic cells.

Abstract
A member of the retinoblastoma family of cell cycle regulatory proteins, p107, is not normally expressed in non-cycling cells. We demonstrate here that p107 is expressed in monocytes as they differentiate into dendritic cells under the influence of granulocyte-macrophage colony-stimulating factor and interleukin 4, a process shown not to involve cellular proliferation. We show that p107 is localized to the nucleus of these cells and is active, in that it binds an E2F-DNA binding site, together with E2F transcription factors. These findings suggest a hitherto unknown role for p107 in non-proliferating dendritic cells that warrants further investigation.
AuthorsK M Ardeshna, F Ahmed, S Devereux, N S Thomas
JournalBritish journal of haematology (Br J Haematol) Vol. 112 Issue 3 Pg. 655-7 (Mar 2001) ISSN: 0007-1048 [Print] England
PMID11260068 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carrier Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Nuclear Proteins
  • RBL1 protein, human
  • Retinoblastoma-Binding Protein 1
  • Retinoblastoma-Like Protein p107
  • Transcription Factor DP1
  • Transcription Factors
  • Interleukin-4
  • Granulocyte-Macrophage Colony-Stimulating Factor
Topics
  • Blotting, Western
  • Carrier Proteins
  • Cell Cycle Proteins
  • Cell Differentiation
  • Cell Nucleus (metabolism)
  • Cells, Cultured
  • DNA-Binding Proteins
  • Dendritic Cells (metabolism)
  • E2F Transcription Factors
  • Granulocyte-Macrophage Colony-Stimulating Factor (pharmacology)
  • Humans
  • Immunohistochemistry
  • Interleukin-4 (pharmacology)
  • Monocytes (cytology, metabolism)
  • Nuclear Proteins (analysis, metabolism)
  • Retinoblastoma-Binding Protein 1
  • Retinoblastoma-Like Protein p107
  • Transcription Factor DP1
  • Transcription Factors (analysis, metabolism)

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