HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Treatment of persistent knee effusions with intra-articular radioactive gold.

Abstract
Patients with a total of 112 chronic knee effusions unresponsive to the usual conservative methods of therapy were treated with intra-articular injections of radioactive gold and followed from 6 months to 5 years. Most patients in the study had rheumatoid arthritis but others had ankylosing spondylitis, psoriatic arthritis, intermittent hydrathrosis and undiagnosed synovitis. After 6 months 81% showed improvement. This figure diminished to approximately 70% at 1 and 2 years, 60% at 3 and 4 years and 50% at 5 years. The mose beneficial results were seen in patients with intermittent hydrarthrosis. Twelve patients with a synovial cyst and/or rupture improved. Patients with thin synovia and anatomic stage I or II disease did best, but those with stage III disease also did well. After the injection 33% of the patients had a reactive synovitis. A variable amount of radioactive material escaped from the knee to the regional lymph nodes and general circulation.
AuthorsJ R Topp, E G Cross, A G Fam
JournalCanadian Medical Association journal (Can Med Assoc J) Vol. 112 Issue 9 Pg. 1085-9 (May 03 1975) ISSN: 0008-4409 [Print] Canada
PMID1125918 (Publication Type: Journal Article)
Chemical References
  • Gold Colloid, Radioactive
Topics
  • Age Factors
  • Arthritis, Rheumatoid (drug therapy)
  • Drug Evaluation
  • Female
  • Follow-Up Studies
  • Gold Colloid, Radioactive (administration & dosage, therapeutic use)
  • Humans
  • Injections, Intra-Articular
  • Joint Diseases (drug therapy, pathology)
  • Knee Joint
  • Male
  • Spondylitis, Ankylosing (drug therapy)
  • Synovitis (drug therapy)
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: