Abstract |
Patients with a total of 112 chronic knee effusions unresponsive to the usual conservative methods of therapy were treated with intra-articular injections of radioactive gold and followed from 6 months to 5 years. Most patients in the study had rheumatoid arthritis but others had ankylosing spondylitis, psoriatic arthritis, intermittent hydrathrosis and undiagnosed synovitis. After 6 months 81% showed improvement. This figure diminished to approximately 70% at 1 and 2 years, 60% at 3 and 4 years and 50% at 5 years. The mose beneficial results were seen in patients with intermittent hydrarthrosis. Twelve patients with a synovial cyst and/or rupture improved. Patients with thin synovia and anatomic stage I or II disease did best, but those with stage III disease also did well. After the injection 33% of the patients had a reactive synovitis. A variable amount of radioactive material escaped from the knee to the regional lymph nodes and general circulation.
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Authors | J R Topp, E G Cross, A G Fam |
Journal | Canadian Medical Association journal
(Can Med Assoc J)
Vol. 112
Issue 9
Pg. 1085-9
(May 03 1975)
ISSN: 0008-4409 [Print] Canada |
PMID | 1125918
(Publication Type: Journal Article)
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Chemical References |
- Gold Colloid, Radioactive
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Topics |
- Age Factors
- Arthritis, Rheumatoid
(drug therapy)
- Drug Evaluation
- Female
- Follow-Up Studies
- Gold Colloid, Radioactive
(administration & dosage, therapeutic use)
- Humans
- Injections, Intra-Articular
- Joint Diseases
(drug therapy, pathology)
- Knee Joint
- Male
- Spondylitis, Ankylosing
(drug therapy)
- Synovitis
(drug therapy)
- Time Factors
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