Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase.
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| Abstract |
Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and beta-adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from beta-NAD+. This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase Cbeta and beta-adrenoceptors to adenylyl cyclase via G proteins. Upon receptor stimulation, the newly-formed cADPR may coordinately function to upregulate the release of Ca2+ from the type II ryanodine receptors as well as to facilitate Ca2+ influx through voltage-dependent Ca2+ channels. cADPR interacts with FK506, an immunosuppressant, at FKBP12.6, FK506-binding-protein, and calcineurin, or ryanodine receptors. cADPR also functions through activating calcineurin released from A-kinase anchoring protein (AKAP79). Thus, some G(q/11)-coupled receptors can control cADPR-dependent modulation in Ca2+ signaling.
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| Authors | H Higashida, S Yokoyama, N Hoshi, M Hashii, A Egorova, Z G Zhong, M Noda, M Shahidullah, M Taketo, R Knijnik, Y Kimura, H Takahashi, X L Chen, Y Shin, J S Zhang |
| Journal | Biological chemistry (Biol Chem) Vol. 382 Issue 1 Pg. 23-30 (Jan 2001) ISSN: 1431-6730 [Print] Germany |
| PMID | 11258666 (Publication Type: Journal Article, Review) |
| Chemical References |
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