Immunoprophylactic strategies against respiratory influenza virus infection.

Abstract

The objective of this report is to evaluate the prophylactic efficacy of liposome-mediated immunotherapy for prevention of respiratory influenza virus infection in mice. Antiviral antibody, interferon-gamma and poly (ICLC) were encapsulated in liposomes and they were evaluated for their ability to induce protective immunity against lethal influenza infection. Passive immunization using liposome-encapsulated antiviral antibody was found to offer complete protection against the virus challenge. However, this pretreatment must be administered within 24 h prior to virus challenge to be protective. Pretreatment with liposome-encapsulated interferon-gamma was found to stimulate cellular immune responses, but the protection is partial. Immunoprophylaxis using liposome-encapsulated double-stranded (ds) RNA poly (ICLC) provided complete and longer-lasting protection against influenza infection. These results suggest liposome-mediated immunoprophylactic approaches are effective in the prevention of respiratory influenza virus infection.

• Authors: E G Saravolac, D Sabuda, C Crist, K Blasetti, G Schnell, H Yang, M Kende, H B Levy, J P Wong
• Journal: Vaccine (Vaccine) Vol. 19 Issue 17-19 Pg. 2227-32 (Mar 21 2001) ISSN: 0264-410X [Print] Netherlands
• PMID: 11257338 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antibodies, Viral
• Liposomes
• Recombinant Proteins
• Interferon-gamma
• Poly I-C

Topics

• Adjuvants, Immunologic (administration & dosage)
• Administration, Intranasal
• Animals
• Antibodies, Viral (administration & dosage)
• Humans
• Immunization, Passive (methods)
• Influenza, Human (immunology, prevention & control)
• Interferon-gamma (administration & dosage)
• Liposomes
• Mice
• Poly I-C (administration & dosage)
• Recombinant Proteins
• Time Factors