Abstract |
We investigated propofol pharmacokinetics in a patient with secondary hyperthyroidism caused by thyroid stimulating hormone (TSH) producing pituitary adenoma. Laboratory data indicated thyrotoxic state with elevated TSH, FT3 and FT4 levels. General anesthesia was maintained with a doubled propofol infusion rate (8-10 mg.kg-1.hr-1) compared to our standard procedure. During 370 min of infusion, propofol concentrations in arterial blood were kept within optimal ranges (2-4 micrograms.ml-1). Although the clearance of propofol was high (2.8 l.min-1) because of the thyrotoxic state, the patient showed delayed recovery from anesthesia. The half-life of blood propofol after the termination of infusion exceeded 30 minutes (normal: 10-15 minutes). We conclude that the delayed recovery was due to the accumulation of propofol in the adipose tissue during long-term infusion in spite of the increased propofol clearance.
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Authors | S Ishizuka, T Tsubokawa, K Yamamoto, T Kobayashi |
Journal | Masui. The Japanese journal of anesthesiology
(Masui)
Vol. 50
Issue 2
Pg. 199-202
(Feb 2001)
ISSN: 0021-4892 [Print] Japan |
PMID | 11244780
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Anesthetics, Intravenous
- Thyrotropin
- Propofol
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Topics |
- Adenoma
(complications, metabolism)
- Anesthesia Recovery Period
- Anesthesia, General
- Anesthetics, Intravenous
(pharmacokinetics)
- Half-Life
- Humans
- Hyperthyroidism
(etiology, metabolism)
- Male
- Middle Aged
- Pituitary Neoplasms
(complications, metabolism)
- Propofol
(pharmacokinetics)
- Thyrotropin
(biosynthesis)
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