Unusual annular erythema associated with myelodysplastic syndrome.

Abstract

We report a case of unusual annular erythema associated with myelodysplastic syndrome (MDS). A 58-year-old male with MDS developed annular erythema on his back, scaly erythema on the dorsa of hands, and exudative erythema on his eyelids. Histological examination revealed a mononuclear cell infiltrate around vessels and follicles in the mid- to lower dermis. He had no history of treatment with granulocyte-colony-stimulating factor (G-CSF). Serum granulocyte-macrophage-colony-stimulating factor (GM-CSF) level was slightly elevated (5.84 pg/ml, normal < 2.0 pg/ml), whereas other cytokines including G-CSF, IL-6, and IL-8 were within normal limits. Skin manifestations were much improved by systemic mepitiostane, and serum GM-CSF level returned to normal levels.

• Authors: T Yamamoto, K Soejima, H Yokozeki, T Koyano, I Katayama, K Nishioka
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 202 Issue 1 Pg. 70-2 ( 2001) ISSN: 1018-8665 [Print] Switzerland
• PMID: 11244236 (Publication Type: Case Reports, Journal Article)

Chemical References

• Androstanols
• Antineoplastic Agents
• Granulocyte-Macrophage Colony-Stimulating Factor
• mepitiostane

Topics

• Aged
• Androstanols (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Erythema (blood, etiology, pathology)
• Granulocyte-Macrophage Colony-Stimulating Factor (blood, drug effects)
• Humans
• Male
• Myelodysplastic Syndromes (complications, drug therapy)
• Skin (drug effects, pathology)