| Abstract | BACKGROUND: Our aim was to study the pharmacokinetics and pain scores following administration of single oral doses of either diclofenac or high-dose acetaminophen (paracetamol). METHODS: In the morning, the day after tonsillectomy, children 5-15 years of age were randomized in a double-blind manner to receive either diclofenac 1-2 mg.kg-1 (n=11) or acetaminophen 22.5 mg.kg-1 (n=10). Postoperative pain was assessed by self-report and blood samples were drawn every 30 min for 4 h after medication. RESULTS: Large interindividual differences in maximum plasma diclofenac concentrations (Cmax) were found. Mean Cmax was 2.4+/-1.3 microg.ml-1 and mean tmax was 2+/-0.5 h. No significant reduction in pain score with diclofenac was seen at any of the assessments during the study period. Eight of 10 children achieved Cmax of acetaminophen within the 10-20 microg.ml-1 antipyretic range. Mean tabs was 0.7+/-0.3 h and mean Cmax and tmax were 12.7+/-3.8 microg ml-1 and 1.4+/-0.5 h, respectively. No significant reduction in pain score with acetaminophen was seen at any of the assessments during the study period. CONCLUSIONS: The achieved concentrations of diclofenac and acetaminophen were not able to significantly reduce the children's pain score during the 5 h postingestion study period. Analgesic plasma acetaminophen concentrations may be higher than those required for antipyresis. |
| Authors | J Rømsing, D Ostergaard, T Senderovitz, D Drozdziewicz, J Sonne, G Ravn
(Affiliation: The Royal Danish School of Pharmacy, Department of Pharmaceutics, 2 Universitetsparken, DK-2100 Copenhagen, Denmark. jr at dfh.dk)
|
| Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 11
Issue 2
Pg. 205-13
(Mar 2001)
ISSN: 1155-5645 France |
| PMID | 11240880
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
| Chemical References |
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents, Non-Steroidal
- Acetaminophen
- Diclofenac
|
| Topics |
- Acetaminophen
(administration & dosage, pharmacokinetics)
- Administration, Oral
- Adolescent
- Analgesics, Non-Narcotic
(administration & dosage, pharmacokinetics)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, pharmacokinetics)
- Child
- Child, Preschool
- Diclofenac
(administration & dosage, pharmacokinetics)
- Double-Blind Method
- Female
- Humans
- Male
- Pain, Postoperative
(drug therapy)
- Tonsillectomy
|
