KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models.

Abstract

KF19418, a newly synthesized compound, stimulated proliferation of cultured hair bulb cells from new born mice in concentration-dependent manner in the range under 10 microM. In the culture system of whole skin pieces from 4-week-old mice which we earlier established, KF19418 promoted hair follicle elongation as in the case of minoxidil. After topical application for 2 weeks of KF19418 or minoxidil to dorsal skin of hair-clipped mouse alopecia model, KF19418 at 1% suspension accelerated hair regrowth at a rate comparable to 1% minoxidil solution. Thus, it was shown that KF19418 directly stimulated hair follicle in vitro and had hair growth promoting activities in vivo.

• Authors: A Shirai, J Ikeda, S Kawashima, T Tamaoki, T Kamiya
• Journal: Journal of dermatological science (J Dermatol Sci) Vol. 25 Issue 3 Pg. 213-8 (Apr 2001) ISSN: 0923-1811 [Print] Netherlands
• PMID: 11240269 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dermatologic Agents
• Heterocyclic Compounds, 3-Ring
• KF19418
• Minoxidil

Topics

• Alopecia (drug therapy, pathology)
• Animals
• Cells, Cultured
• Culture Techniques
• Dermatologic Agents (pharmacology)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Hair (drug effects, growth & development)
• Hair Follicle (drug effects, growth & development)
• Heterocyclic Compounds, 3-Ring (pharmacology)
• Male
• Mice
• Mice, Inbred C3H
• Minoxidil (pharmacology)