| Abstract | PURPOSE: To determine the changes in serum levels of proinflammatory cytokines within 48 h after selective internal radiation treatment (SIRT) in patients with advanced liver cancers. METHODS AND MATERIALS: Twenty-eight patients with advanced liver cancers who underwent SIRT were recruited into the study. Serum levels of interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor-alpha, and interferon-gamma were determined prior to and 3, 6, 12, 24, and 48 h after SIRT. Their changes were correlated to adverse reactions following treatment as assessed by constitutional symptom scores, and routine blood and liver function tests at 24 and 48 h post-SIRT and falls in serum carcinoembryonic antigen (CEA) level 1 month post-SIRT. RESULTS: Serum IL-6 levels were significantly increased at 24 (p < or = 0.05) and 48 h (p < or = 0.01) post-SIRT. In contrast, there was no significant change in the serum levels of other cytokines studied. The increase in serum IL-6 at 24 h post-SIRT was significantly correlated with the changes in serum alanine transferase (p < or = 0.05) and C-reactive protein (p < or = 0.001) levels and total leukocyte counts (p < or = 0.001) at both 24 and 48 h post-SIRT. Changes in serum IL-6 level were also significantly correlated to the rise of serum aspartate transaminase levels at 48 h post-SIRT (p < or = 0.001), but not with the scores of constitutional symptoms or the changes of serum CEA at 1 month post-SIRT. CONCLUSION: Absence of significant changes in most of proinflammatory cytokines studied confirmed that SIRT is a reasonably safe and well-tolerated treatment with minimal side-effect from the point of view of cytokine-related inflammation. The correlation of serum IL-6 changes with several liver enzymes and C-reactive protein but not with clinical symptom scores or serum CEA levels suggests that the rise in IL-6 levels in the first 48 h following SIRT most likely reflect normal liver cell damage rather than tumor cell damage. |
| Authors | J K Wickremesekera, W Chen, R J Cannan, R S Stubbs
(Affiliation: Wakefield Gastroenterology Centre and Research Institute, Wakefield Hospital, Wellington, Newtown, New Zealand.)
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| Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 49
Issue 4
Pg. 1015-21
(Mar 15 2001)
ISSN: 0360-3016 United States |
| PMID | 11240242
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Carcinoembryonic Antigen
- Interleukin-6
- Interleukins
- Neoplasm Proteins
- Tumor Necrosis Factor-alpha
- Yttrium Radioisotopes
- Interferon-gamma
- C-Reactive Protein
- Aspartate Aminotransferases
- Alanine Transaminase
|
| Topics |
- Adult
- Aged
- Alanine Transaminase
(blood)
- Aspartate Aminotransferases
(blood)
- Brachytherapy
(adverse effects, methods)
- C-Reactive Protein
(metabolism)
- Carcinoembryonic Antigen
(blood)
- Female
- Humans
- Interferon-gamma
(blood)
- Interleukin-6
(blood)
- Interleukins
(blood)
- Leukocyte Count
- Liver Neoplasms
(blood, radiotherapy)
- Male
- Microspheres
- Middle Aged
- Neoplasm Proteins
(blood)
- Time Factors
- Tumor Necrosis Factor-alpha
(metabolism)
- Yttrium Radioisotopes
(therapeutic use)
|
