HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Systemic EMD 68843 injections reduce anxiety in the shock-probe, but not the plus-maze test.

Abstract
Selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors and 5-HT(1A) receptor agonists are believed to reduce anxiety. In the present study we examined the effects of injections of 5-(4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide hydrochloride salt (EMD 68843), a 5-HT(1A) receptor agonist and selective 5-HT reuptake inhibitor, in two animal models of anxiety, plus-maze and shock-probe. Rats received intraperitoneal injections of vehicle, diazepam (2.5 mg/kg), or EMD 68843 (10, 20, or 40 mg/kg) 1 h prior to testing. Diazepam at the single dose tested and EMD 68843 dose-dependently (significantly at 20 and 40 mg/kg) reduced burying in shock-probe. However, only diazepam significantly increased open arm exploration in the plus-maze. Therefore, EMD 68843 has task specific anxiolytic properties.
AuthorsD Treit, A Degroot, S kashluba, G D Bartoszyk
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 414 Issue 2-3 Pg. 245-8 (Mar 02 2001) ISSN: 0014-2999 [Print] Netherlands
PMID11239925 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Anxiety Agents
  • Benzofurans
  • Indoles
  • Piperazines
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Uptake Inhibitors
  • Diazepam
  • Vilazodone Hydrochloride
Topics
  • Animals
  • Anti-Anxiety Agents (therapeutic use)
  • Anxiety (drug therapy)
  • Benzofurans (therapeutic use)
  • Diazepam (therapeutic use)
  • Electric Stimulation
  • Indoles (therapeutic use)
  • Male
  • Maze Learning
  • Piperazines
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Serotonin (drug effects, physiology)
  • Receptors, Serotonin, 5-HT1
  • Selective Serotonin Reuptake Inhibitors (therapeutic use)
  • Vilazodone Hydrochloride

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: