Successful use of cyclooxygenase-2 inhibitor in a patient with aspirin-induced asthma.

Abstract

We describe the case of an aspirin-sensitive asthma patient with a history of anaphylactic reactions to nonsteroidal anti-inflammatory drugs. The patient was subsequently diagnosed with rheumatoid arthritis and treated with a cyclooxygenase (COX)-2 inhibitor without an adverse response. Current prescribing information warns to avoid using COX-2 inhibitors in aspirin-sensitive asthma patients. New evidence suggests that aspirin sensitivity may be linked to the COX-1 pathway, and COX-2 inhibitors, as a result of their selectivity, may be beneficial in patients with aspirin-induced asthma.

• Authors: F Marks, K Harrell, R Fischer
• Journal: Southern medical journal (South Med J) Vol. 94 Issue 2 Pg. 256-7 (Feb 2001) ISSN: 0038-4348 [Print] United States
• PMID: 11235048 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors
• Isoenzymes
• Membrane Proteins
• Pyrazoles
• Sulfonamides
• Cyclooxygenase 2
• PTGS2 protein, human
• Prostaglandin-Endoperoxide Synthases
• Celecoxib
• Aspirin

Topics

• Aged
• Anaphylaxis (chemically induced)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, therapeutic use)
• Arthritis, Rheumatoid (drug therapy)
• Aspirin (adverse effects)
• Asthma (chemically induced)
• Celecoxib
• Cyclooxygenase 2
• Cyclooxygenase 2 Inhibitors
• Cyclooxygenase Inhibitors (therapeutic use)
• Female
• Humans
• Isoenzymes (antagonists & inhibitors)
• Membrane Proteins
• Prostaglandin-Endoperoxide Synthases
• Pyrazoles
• Sulfonamides (therapeutic use)