Abstract |
It has previously been reported that rats kindled via the standard kindling procedure do not exhibit the typical profile of neuropathology following status epilepticus. We wished to determine whether a 1-day rapid kindling procedure is also neuroprotective against cell damage resulting from prolonged seizure activity. We found that rats rapidly kindled from the dorsal hippocampus were more resistant to a kainic acid challenge 21-25 days after kindling than were unkindled control rats. Kindling prior to a kainic acid challenge also provided substantial protection against status epilepticus-induced damage in the CA3 region of the hippocampus and piriform cortex in most animals. Thus, despite the short kindling time period, rapid kindling is neuroprotective against status epilepticus-induced cell damage.
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Authors | M R Penner, R Pinaud, H A Robertson |
Journal | Neuroreport
(Neuroreport)
Vol. 12
Issue 3
Pg. 453-7
(Mar 05 2001)
ISSN: 0959-4965 [Print] England |
PMID | 11234745
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Excitatory Amino Acid Agonists
- Kainic Acid
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Topics |
- Adaptation, Physiological
(physiology)
- Animals
- Cell Survival
(physiology)
- Cerebral Cortex
(pathology, physiology)
- Excitatory Amino Acid Agonists
- Hippocampus
(pathology, physiology)
- Kainic Acid
- Kindling, Neurologic
(physiology)
- Male
- Neurons
(pathology, physiology)
- Rats
- Rats, Long-Evans
- Status Epilepticus
(chemically induced, pathology, physiopathology)
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