HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The role of angiotensin receptor blockers in the management of chronic heart failure.

Abstract
Clinical and basic science research has repeatedly confirmed the importance of the renin-angiotensin-aldosterone system in the pathophysiology of chronic heart failure. Accordingly, blockade of this system by angiotensin-converting enzyme (ACE) inhibitors has assumed a central role in the treatment of heart failure. Recently, angiotensin II receptor blockers (ARBs) have gained prominence as a possible substitute for ACE inhibitors in therapy for heart failure. However, clinical data compiled on this use of ARBs have shown them to be useful only as alternative therapy in ACE inhibitor-intolerant patients. Continuing large-scale clinical investigations may lead to an expansion of their role in therapy for various cardiovascular diseases.
AuthorsA H Jamali, W H Tang, U N Khot, M B Fowler
JournalArchives of internal medicine (Arch Intern Med) Vol. 161 Issue 5 Pg. 667-72 (Mar 12 2001) ISSN: 0003-9926 [Print] United States
PMID11231698 (Publication Type: Journal Article, Review)
Chemical References
  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Angiotensin II
  • Losartan
  • Bradykinin
Topics
  • Angiotensin II (antagonists & inhibitors)
  • Angiotensin Receptor Antagonists
  • Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
  • Bradykinin (physiology)
  • Chronic Disease
  • Clinical Trials as Topic
  • Forecasting
  • Heart Failure (drug therapy, physiopathology)
  • Humans
  • Losartan (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: