Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons.

Abstract

The netrin family of axon guidance cues has been shown to play a pivotal role in the guidance of a variety of axon projections during embryonic development, both in the vertebrate and invertebrate. While the guidance potential of netrin-1 has been examined in depth in many regions of the developing mouse brain very little information is available on the expression and activity of netrin-3. Here we show that the netrin-3 protein is present on motor neurons and subpopulations of neurons within sensory and sympathetic ganglia. Moreover, significant levels of netrin-3 protein were found to be associated with the axons projecting from these neurons suggesting a role for netrin-3 in axon pathfinding and fasciculation within the peripheral nervous system.

• Authors: C Seaman, H M Cooper
• Journal: Mechanisms of development (Mech Dev) Vol. 101 Issue 1-2 Pg. 245-8 (Mar 2001) ISSN: 0925-4773 [Print] Ireland
• PMID: 11231084 (Publication Type: Journal Article)

Chemical References

• Nerve Tissue Proteins
• Netrins
• netrin-3

Topics

• Animals
• Axons (metabolism)
• Brain (embryology)
• Immunohistochemistry
• Mice
• Molecular Sequence Data
• Nerve Tissue Proteins (biosynthesis)
• Netrins
• Neural Crest (embryology)
• Neurons (metabolism)
• Time Factors
• Tissue Distribution
• Trigeminal Ganglion (embryology)