| Abstract | The aim of study was the evaluation of efficacy of specific immunotherapy using Alavac S HDM for 2-4 years in children with atopic bronchial asthma induced by Deramtophagoides pteronyssinus. The study was carried out in a group of 33 children aged 5-18 years, from the Outpatient Department of Immunology at the National Research Institute of Mother and Child. The children demonstrated clinical symptoms of asthma and had a medical history typical for this disease. Diagnostic procedures including skin prick tests and estimation of specific IgE to Dermatophagoides pteronyssinus by Pharmacia-CAP system gave positive results. The efficacy of therapy was monitored by a clinical score of symptoms with 0-10-20-30 points, recording symptoms relating to intensity of dyspneaa, wheezing, cough, value of PEF and concomitant medications for example corticoids and beta-antagonists. In the study group, 31 children (94%) with asthma treated by specific immunotherapy (AlavacS HDM) improved. This was confirmed by a statistically significant difference. The results indicate that specific immunotherapy is effective in the treatment of asthma in children sesitized to Dermatophagoides pteronyssinus. |
| Authors | E Bulawa, M Wawrzyniak
(Affiliation: Zaklad Immunologii, Instytut Matki i Dziecka, Kasprzaka 17a, 01-211, Warszawa, Poland. imid at imid.med.pl)
|
| Journal | Medycyna wieku rozwojowego
(Med Wieku Rozwoj)
2000 Oct-Dec
Vol. 4
Issue 4
Pg. 355-62
ISSN: 1428-345X Poland |
| Vernacular Title | Skuteczność immunoterapii swoistej u dzieci chorych na asthme oskrzelowa, uczulonych na roztocza kurzu domowego. |
| PMID | 11228593
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Alavac S
- Anti-Allergic Agents
- Antigens, Dermatophagoides
- Bacterial Vaccines
- Glycoproteins
|
| Topics |
- Adolescent
- Anti-Allergic Agents
(therapeutic use)
- Antigens, Dermatophagoides
- Asthma
(therapy)
- Bacterial Vaccines
(therapeutic use)
- Child
- Child, Preschool
- Desensitization, Immunologic
- Glycoproteins
(immunology)
- Humans
- Immunotherapy
- Treatment Outcome
|
