Abstract | BACKGROUND/PURPOSE: METHODS: In a prospective, randomized, double-blinded trial, 90 pediatric patients, aged 4 to 10 years, received granisetron, 40 microg/kg; droperidol, 50 microg/kg; or metoclopramide, 0.25 mg/kg ( n = 30 of each) intravenously after an inhalation induction of anesthesia. Emetic episodes and safety assessments were performed during the first 24 hours after anesthesia. RESULTS: Twenty-two of 30 patients (73%) who had received granisetron were emesis free during the first 24 hours after surgery as compared with 7 of 30 (23%) who had received droperidol (P <.05) or 6 of 30 (20%) who had received metoclopramide (P <.05). No clinically serious adverse events were observed in any of the groups. CONCLUSION:
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Authors | Y Fujii, H Tanaka |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 36
Issue 3
Pg. 460-2
(Mar 2001)
ISSN: 0022-3468 [Print] United States |
PMID | 11226996
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antiemetics
- Metoclopramide
- Droperidol
- Granisetron
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Topics |
- Analysis of Variance
- Antiemetics
(therapeutic use)
- Child, Preschool
- Double-Blind Method
- Droperidol
(therapeutic use)
- Female
- Granisetron
(therapeutic use)
- Humans
- Infant
- Injections, Intravenous
- Intraoperative Care
- Male
- Metoclopramide
(therapeutic use)
- Motion Sickness
- Postoperative Nausea and Vomiting
(prevention & control)
- Prospective Studies
- Statistics, Nonparametric
- Tonsillectomy
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