Hematological studies on DIC-like findings observed in patients with snakebite in south China.

To clarify the characteristics of the hematological disturbances evoked by snakebite, we measured the antithrombin III (AT-III) activity, alpha2-plasmin inhibitor (alpha2-PI) activity, fibrinogen concentration (Fg) and level of fibrin degradation products (FDP) in 21 patients envenomed by several snakes in south China between August 1998 and October 1999. The hematological changes observed were as follows: the mean activities of AT-III were decreased in patients bitten by Ophiophagus hannah (Oh.), Bungarus fasciatus (Bf.), Hydrophis cyanocinctus (Hc.), Rhabdophis subminiatus (Rs.), and Trimeresurus stejnegeri (Ts.), while those of alpha2-PI were decreased in all patients in the present study; Fg was not detectable in the case of Rs. bite, and the Fg concentration after Ts., Oh., Hc. and Bf. bites also decreased markedly thereby increasing the mean levels of FDP in all patients. It thus appeared that DIC-like syndrome was caused in patients envenomed by snakebite. In the present study, we found that patients who were bitten by Rs., which is still being classified as a non-venomous snake, exhibited complete defibrinogenation and severe hemorrhage without any evidence of severe multiple organ damage. We also found that patients with Ts. bite showed marked hemostatic disturbance without severe multiple organ damage. It is considered that such a discrepancy between the hematological findings and clinical symptoms could be a characteristic phenomenon of the DIC-like syndrome induced by snakebite, especially by Rs. and Ts. bites.
AuthorsQ B Li, G W Huang, K Kinjoh, M Nakamura, T Kosugi
JournalToxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 39 Issue 7 Pg. 943-8 (Jul 2001) ISSN: 0041-0101 [Print] England
PMID11223082 (Publication Type: Journal Article)
Chemical References
  • Fibrin Fibrinogen Degradation Products
  • Indicators and Reagents
  • alpha-2-Antiplasmin
  • Antithrombin III
  • Fibrinogen
  • Antithrombin III (metabolism)
  • China
  • Disseminated Intravascular Coagulation (blood)
  • Fibrin Fibrinogen Degradation Products (metabolism)
  • Fibrinogen (metabolism)
  • Humans
  • Indicators and Reagents
  • Snake Bites (blood)
  • alpha-2-Antiplasmin (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: