[Abciximab (ReoPro) in the treatment of acute coronary syndromes].

Abstract

Platelet activation plays a major role in the pathophysiology of acute coronary syndromes (ACS). Inhibition of platelet function is the basic pharmacological treatment of ACS. Platelet membrane glycoprotein IIb/IIIa inhibitors, a new class of potent antiplatelet agents, have been used in the treatment of ACS and in the prevention of complications after percutaneous coronary interventions (PCI). Several large clinical trials have demonstrated the effectiveness of this class of agents. The first of these agents to show beneficial effects after coronary interventions was the mouse/human chimeric Fab fragment antibody c7E3 abciximab (ReoPro). The purpose of this article is to describe the pharmacology of abciximab and to review the results of the clinical trials carried out with the drug in patients with ACS, treated either with or without acute/elective PCI.

• Authors: L H Rasmussen, S E Husted, E Kassis, J Kastrup, S D Kristensen, K E Pedersen, P Grande
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 163 Issue 4 Pg. 472-7 (Jan 22 2001) ISSN: 0041-5782 [Print] Denmark
• Vernacular Title: Abciximab (ReoPro) ved behandling af akutte koronare syndromer.
• PMID: 11218792 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Platelet Aggregation Inhibitors
• Platelet Glycoprotein GPIIb-IIIa Complex

Topics

• Angioplasty, Balloon, Coronary
• Controlled Clinical Trials as Topic
• Coronary Disease (drug therapy)
• Humans
• Myocardial Infarction (drug therapy)
• Platelet Aggregation Inhibitors (administration & dosage, adverse effects, chemistry)
• Platelet Glycoprotein GPIIb-IIIa Complex (antagonists & inhibitors, drug effects)
• Risk Factors