Abstract | PURPOSE: METHODS: The authors performed gas compression vitrectomy in the right eyes of 29 New Zealand white rabbits. They then inserted a 5-mg GCV implant into the vitreous cavity through an inferotemporal sclerotomy. Saline (1 cc), silicone oil 0.5 cc, or silicone oil 1.0 cc was then injected into the midvitreous cavity of 9, 8, and 12 rabbits, respectively. On postoperative days 21, 42, and 70, the rabbits were killed and the right eyes were immediately collected and stored at -70 degrees C until all samples were obtained. Vitreous was then isolated and drug levels were determined by high-pressure liquid chromatography. RESULTS: Vitreous GCV levels at days 21 and 42 were similar in both the saline-filled and silicone oil-filled eyes. At day 70, GCV levels in both the saline- and silicone-filled eyes were statistically significantly lower than at day 21 (P < 0.05 for all groups). In addition, at day 70, GCV levels in the saline-filled eyes were significantly lower than in silicone-filled eyes (saline versus 0.5 cc oil, P = 0.01; saline versus 1 cc oil, P = 0.09). CONCLUSIONS:
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Authors | S L Perkins, C H Yang, P A Ashton, G J Jaffe |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 21
Issue 1
Pg. 10-4
( 2001)
ISSN: 0275-004X [Print] United States |
PMID | 11217923
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antiviral Agents
- Drug Implants
- Fluorocarbons
- Silicone Oils
- perflutren
- Ganciclovir
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Topics |
- Animals
- Antiviral Agents
(pharmacokinetics)
- Chromatography, High Pressure Liquid
- Drug Implants
- Fluorocarbons
(administration & dosage)
- Ganciclovir
(pharmacokinetics)
- Rabbits
- Silicone Oils
(administration & dosage)
- Vitrectomy
- Vitreous Body
(metabolism)
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