Abstract | OBJECTIVES: BACKGROUND: METHODS: The outcomes of 429 patients from 153 sites in the Platelet glycoprotein IIb/IIIa in unstable angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) trial, who were transferred during study drug infusion ("transfer patients"), were compared with those of 1,987 patients who either remained in the hospital at those sites or were transferred after study drug termination ("nontransfer patients"). RESULTS: The baseline characteristics of transfer and nontransfer patients were similar. Patients receiving eptifibatide were transferred less frequently than those receiving placebo (16% vs. 20%, p = 0.014). Transfer patients underwent more procedures and experienced a greater 30-day incidence of death or MI, as compared with nontransfer patients (21% vs. 12%, p = 0.001). Eptifibatide was associated with a reduction in death or MI through 30 days, independent of transfer status (2.5% absolute reduction), as well as for those transferred (5.5% absolute reduction). CONCLUSIONS: For patients with ACS admitted to community hospitals, eptifibatide is associated with a reduced need for transfer and improved clinical outcomes.
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Authors | A B Greenbaum, R A Harrington, M P Hudson, C M MacAulay, R G Wilcox, M L Simoons, L G Berdan, A Guerci, D V Cokkinos, M M Kitt, A M Lincoff, E J Topol, R M Califf, E M Ohman |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 37
Issue 2
Pg. 492-8
(Feb 2001)
ISSN: 0735-1097 [Print] United States |
PMID | 11216968
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Peptides
- Platelet Aggregation Inhibitors
- Eptifibatide
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Topics |
- Aged
- Coronary Disease
(drug therapy, mortality)
- Eptifibatide
- Female
- Hospitals, Community
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(drug therapy, mortality)
- Myocardial Revascularization
- Patient Transfer
- Peptides
(adverse effects, therapeutic use)
- Platelet Aggregation Inhibitors
(adverse effects, therapeutic use)
- Referral and Consultation
- Survival Rate
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