| Abstract | STUDY OBJECTIVE: To characterize frequency of liver enzyme elevation in patients with type 2 diabetes mellitus receiving troglitazone. DESIGN: Retrospective study. SETTING: Hospital-affiliated medical center. PATIENTS: Two hundred ninety-one patients with type 2 diabetes mellitus. INTERVENTION: Data from patients with an average troglitazone exposure of 412.7 +/- 255.6 days were studied. MEASUREMENTS and MAIN RESULTS: Enzyme elevations more than 1.5 times the upper limit of normal (ULN) occurred in 17 patients (5.8%) and more than 3-fold elevations in 6 (2.1%). The relationship among enzyme elevation events, demographic factors, duration of troglitazone exposure, frequency of monitoring, and concurrent drugs (limited to glucose and lipid-lowering agents) was assessed by multiple logistic regression. Age was an independent predictor of risk (p=0.009), and concurrent insulin therapy approached statistical significance (p=0.051) for 1.5-fold ULN elevation in liver enzymes. Age and concurrent therapy with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors were the only significant predictors of 3-fold ULN elevations (p=0.03 and p=0.04, respectively). CONCLUSION: Several factors appear to increase the risk of enzyme elevation events in patients treated with troglitazone. |
| Authors | J V St Peter, K L Neafus, M A Khan, J T Vessey, M S Lockheart
(Affiliation: Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA.)
|
| Journal | Pharmacotherapy
(Pharmacotherapy)
Vol. 21
Issue 2
Pg. 183-8
(Feb 2001)
ISSN: 0277-0008 United States |
| PMID | 11213855
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Thiazoles
- Thiazolidinediones
- 2,4-thiazolidinedione
- Aspartate Aminotransferases
- Alanine Transaminase
|
| Topics |
- Adult
- Age Factors
- Aged
- Alanine Transaminase
(blood, drug effects)
- Aspartate Aminotransferases
(blood, drug effects)
- Chi-Square Distribution
- Diabetes Mellitus, Type 2
(blood, enzymology)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(blood)
- Liver
(enzymology)
- Male
- Middle Aged
- Multivariate Analysis
- Retrospective Studies
- Statistics, Nonparametric
- Thiazoles
(blood, pharmacology)
- Thiazolidinediones
|
