[Correlation between mantoux and tuberculin's fraction from delayed hypersensitivity skin test, in a cohort from HIV-1 positive patients, in function of immunodeficiency level, and active tuberculosis incidence].

Abstract

OBJECTIVES:

The aim of this work was to assess cellular immunity using the multitest CMI and relate its results with lymphocyte CD4 counts, and the risk to developed active tuberculosis if the multi-test's tuberculosis pápula was positive.

METHODS:

Prospective longitudinal follow-up of 342 IDU patients, 210 infected with HIV-1 and seronegative 132 patients. The cohort study was 165 IDU HIV-1 positive patients (128 men, 37 female). Ages was 18 to 45 years. Study time were 25 months (8-25). Tuberculin skin tests and multitest IMC were performed at baseline and each three months, and screening from active tuberculosis were performed all study when necessary was considered.

RESULTS:

Actived tuberculosis developed in 9.25 cases per one hundred persons and year from follow-up in the ranges with better immunologic status (Score from PHR > 10 mm). There are an significative correlation between tuberculosis skin test diameter and PHR tuberculin fraction papula.

CONCLUSIONS:

PHR performed with Multitest IMC is an useful test to evaluate cellular immune system, and HIV-1 positive patients with energy in this test or positive tuberculine fraction must be considered to isoniazid (9 months) prophylaxis.

• Authors: A Cabarcos Ortiz de Barrón, E Barrio Gómez, F L Lado Lado, I Rodríguez López, V Lorenzo Zúñiga
• Journal: Anales de medicina interna (Madrid, Spain : 1984) (An Med Interna) Vol. 17 Issue 12 Pg. 632-6 (Dec 2000) ISSN: 0212-7199 [Print] Spain
• Vernacular Title: Correlación entre el mantoux y la fracción tuberculínica de la prueba de hipersensibilidad retardada, en una cohorte de pacientes VIH+, en función de su nivel de inmunodeficiencia, e incidencia de tuberculosis activa.
• PMID: 11213577 (Publication Type: English Abstract, Journal Article)

Topics

• AIDS-Related Opportunistic Infections (diagnosis, immunology)
• Adult
• CD4 Lymphocyte Count
• Female
• HIV Infections (immunology)
• HIV-1
• Humans
• Hypersensitivity, Delayed
• Longitudinal Studies
• Male
• Tuberculin Test
• Tuberculosis (diagnosis, immunology)