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Beta-aminocinnamonitriles as potential antiinflammatory agents.

Abstract
A number of beta-aminocinnamonitriles have been prepared by the reaction of salts of acetonitrile and propionitrile with benzonitrile. These materials were evaluated in the carrageenan antiinflammatory screen in Royal Hart, Wistar strain rats. Despite good weight gains in the parent molecule, beta-aminocinnamonitrile (1), only marginal activity was found in related compounds and some possible "metabolites."
AuthorsS A Lang Jr, E Cohen
JournalJournal of medicinal chemistry (J Med Chem) Vol. 18 Issue 4 Pg. 441-3 (Apr 1975) ISSN: 0022-2623 [Print] United States
PMID1121013 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Cinnamates
  • Nitriles
  • Carrageenan
Topics
  • Animals
  • Anti-Inflammatory Agents (chemical synthesis, therapeutic use)
  • Carrageenan
  • Cinnamates (chemical synthesis, therapeutic use)
  • Edema (chemically induced, drug therapy)
  • Erythema (drug therapy, etiology)
  • Guinea Pigs
  • Nitriles (chemical synthesis, therapeutic use)
  • Rats
  • Ultraviolet Rays

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