Immunotoxicity of cupravit and previcur fungicides in mice.

Female mice received either cupravit or previcur at dose levels of 300 ppm and 1000 ppm, respectively, for 8 weeks. Humoral immune response was evaluated by measuring the plaque-forming cell (PFC) response and hemolysing antibody titers against sheep red blood cells (SRBCs), a T lymphocyte-dependent antigen. In addition, the hemagglutinating antibody titers against Escherichia coli lipopolysaccharide (LPS), a T cell-independent antigen, were determined. Both cupravit and previcur suppressed the PFC response by 74% and 78% of control values, respectively. The primary hemolysin antibody titers were reduced to 62% and 76% of control values, respectively. The hemagglutinating antibody titers were decreased to 66% and 77% of control values, respectively. Memory function was reduced as evidenced by inhibition of secondary hemolysin titers to SRBCs. Cell-mediated immunity was inhibited by both cupravit and previcur as evidenced by reduced delayed-type hypersensitivity (DTH) reaction to tuberculin to 77% and 76% of control values, respectively. Decreases in total leukocytic and lymphocytic counts were recorded together with histopathological changes in spleen and thymus gland of intoxicated animals.
AuthorsH S Elsabbagh, O S El-Tawil
JournalPharmacological research (Pharmacol Res) Vol. 43 Issue 1 Pg. 71-6 (Jan 2001) ISSN: 1043-6618 [Print] England
PMID11207068 (Publication Type: Journal Article)
CopyrightCopyright 2001 Academic Press.
Chemical References
  • Antibodies, Bacterial
  • Carbamates
  • Fungicides, Industrial
  • Lipopolysaccharides
  • propamocarb
  • Animals
  • Antibodies, Bacterial (biosynthesis)
  • Antibody Formation (drug effects)
  • Carbamates (toxicity)
  • Female
  • Fungicides, Industrial (toxicity)
  • Immunity (drug effects)
  • Immunity, Cellular (drug effects)
  • Lipopolysaccharides (immunology)
  • Mice
  • Mice, Inbred Strains
  • Sheep
  • Spleen (drug effects, immunology)
  • Thymus Gland (drug effects, immunology)

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