The ameliorating effect of the water layer of Fructus Schisandrae on cycloheximide-induced amnesia in rats: interaction with drugs acting at neurotransmitter receptors.

Abstract

Our previous study indicated that the water layer present in Fructus Schisandra(FS(w)) at 10 and 25 mg kg(-1)significantly counteracted cycloheximide (CXM)-induced amnesia. Therefore, the mechanism of action of the ameliorating effect of FS(w)on CXM-induced amnesia in the passive avoidance task was investigated in rats. The ameliorating effect of FS(w)on CXM-induced amnesia was depressed by scopolamine. The serotonin releaser, p -chloroamphetamine significantly antagonized the ameliorating effect of FS(w)on CXM-induced amnesia. Furthermore, the ameliorating effect was also inhibited by the 5-HT(1A)receptor agonist 8-OH-DPAT, but potentiated by the 5-HT(2)receptor antagonist ritanserin. Finally, the GABA(A)receptor antagonist bicuculline blocked the ameliorating effect of FS(w). These results suggest that the beneficial effect of FS(w)on CXM-induced amnesia is amplified by treatment with serotonergic 5-HT(2)receptor antagonists, but reduced by serotonergic 5-HT(1A)receptor agonists as well as GABA(A)and cholinergic receptor antagonists.

• Authors: M T Hsieh, C R Wu, W H Wang, L W Lin
• Journal: Pharmacological research (Pharmacol Res) Vol. 43 Issue 1 Pg. 17-22 (Jan 2001) ISSN: 1043-6618 [Print] Netherlands
• PMID: 11207061 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2001 Academic Press.

Chemical References

• Cyclooctanes
• Drugs, Chinese Herbal
• Lignans
• Polycyclic Compounds
• Receptors, Neurotransmitter
• Water
• Ritanserin
• p-Chloroamphetamine
• Cycloheximide
• Scopolamine
• schizandrin
• Bicuculline

Topics

• Administration, Oral
• Amnesia (chemically induced, metabolism, prevention & control)
• Animals
• Bicuculline (administration & dosage, metabolism)
• Cycloheximide (pharmacology)
• Cyclooctanes
• Drugs, Chinese Herbal (therapeutic use)
• Lignans (therapeutic use)
• Male
• Phytotherapy
• Plants, Medicinal (therapeutic use)
• Polycyclic Compounds (therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Reaction Time (drug effects)
• Receptors, Neurotransmitter (metabolism)
• Ritanserin (administration & dosage, metabolism)
• Scopolamine (administration & dosage, metabolism)
• Water (chemistry)
• p-Chloroamphetamine (administration & dosage, metabolism)