The impact of expression of the metastasis suppressor protein KAI1 on prognosis in invasive squamous cell cervical cancer.

Abstract

OBJECTIVES:

Loss of KAI1 protein is a frequent event in various types of cancer and has been reported to be associated with increased rate of metastasis and shorter survival time.

METHODS:

Expression of KAI1 and p53 was immunohistochemically determined in 75 biopsy specimens from patients with primary irradiated, invasive squamous cell cervical cancer and 30 cases with CIN I-III.

RESULTS:

In invasive cancer, 22 cases showed strong expression, 42 cases down-regulation, and 11 cases no expression of KAI1. All specimens with CIN I showed strong KAI1 expression, while in CIN II and III down-regulation was observed in 45% of cases. There was no significant correlation of KAI1 expression with clinical and histopathological parameters. No influence of KAI1 expression on prognosis was observed.

CONCLUSIONS:

KAI1-down-regulation is a frequent event in cervical cancer occurring early in carcinogenesis. KAI1 expression did not influence the prognosis of patients with primary irradiated cervical cancer.

• Authors: M Schindl, P Birner, B Bachtiary, G Breitenecker, E Selzer, G Oberhuber
• Journal: Anticancer research (Anticancer Res) 2000 Nov-Dec Vol. 20 Issue 6B Pg. 4551-5 ISSN: 0250-7005 [Print] Greece
• PMID: 11205303 (Publication Type: Journal Article)

Chemical References

• Antigens, CD
• CD82 protein, human
• Kangai-1 Protein
• Membrane Glycoproteins
• Neoplasm Proteins
• Proto-Oncogene Proteins
• Tumor Suppressor Protein p53

Topics

• Antigens, CD (metabolism)
• Carcinoma, Squamous Cell (metabolism, pathology)
• Cervix Uteri (metabolism)
• Disease-Free Survival
• Down-Regulation
• Female
• Humans
• Kangai-1 Protein
• Membrane Glycoproteins (metabolism)
• Middle Aged
• Neoplasm Proteins (metabolism)
• Prognosis
• Proto-Oncogene Proteins
• Tumor Suppressor Protein p53 (metabolism)
• Uterine Cervical Neoplasms (metabolism, pathology)
• Uterine Cervical Dysplasia (metabolism, pathology)