Abstract | BACKGROUND: METHODS: RESULTS: The beagles tolerated the treatment well, with no side effects noted either clinically or by routine CBC or blood chemistry analyses. In contrast, the first two tumor-bearing dogs accrued onto the phase I study developed acute pancreatitis in the immediate post-treatment period which necessitated hospitalization and intensive care. The trial was stopped. Both dogs had intercurrent risk factors which predisposed them to development of pancreatitis, although neither had a history of symptoms of pancreatitis at the time the hyperthermia + L-NAME treatment was given. CONCLUSIONS: We conclude that caution should be exercised when considering NOS inhibition for cancer treatment. Careful evaluation of history and health status as well as recognition of potential risk factors may be key in avoiding potentially fatal complications. This study demonstrates the value of performing potentially harmful treatments in tumor-bearing dogs prior to introduction into the human clinic.
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Authors | J M Poulson, M W Dewhirst, A A Gaskin, Z Vujaskovic, T V Samulski, D M Prescott, R E Meyer, R L Page, D E Thrall |
Journal | In vivo (Athens, Greece)
(In Vivo)
2000 Nov-Dec
Vol. 14
Issue 6
Pg. 709-14
ISSN: 0258-851X [Print] Greece |
PMID | 11204486
(Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Enzyme Inhibitors
- Nitric Oxide Synthase
- NG-Nitroarginine Methyl Ester
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Topics |
- Acute Disease
- Animals
- Bone Neoplasms
(drug therapy, veterinary)
- Combined Modality Therapy
- Dogs
- Enzyme Inhibitors
(adverse effects)
- Fatal Outcome
- Female
- Fibrosarcoma
(drug therapy, veterinary)
- Hyperthermia, Induced
- Male
- NG-Nitroarginine Methyl Ester
(adverse effects)
- Neovascularization, Pathologic
(drug therapy, veterinary)
- Nitric Oxide Synthase
(antagonists & inhibitors)
- Orbital Neoplasms
(drug therapy, veterinary)
- Pancreatitis
(chemically induced, veterinary)
- Sarcoma
(drug therapy, veterinary)
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