[Anti-arrhythmic effect of the sigma-receptor blocker DuP 734 in ischemia and myocardial reperfusion].

Abstract

It has been found that in vivo pretreatment of rats with the sigma receptor antagonist DuP 734 (1 mg/kg) resulted in an increase in the heart tolerance to ischemic and reperfusion arrhythmias both in vivo and ex vivo. Administration of DuP 734 (1 mg/liter) directly in the perfusion solution of isolated rat heart 10 min before total ischemia also promoted a decrease in the incidence of reperfusion arrhythmias. The normoxic perfusion of isolated rat heart at a dose of 1 mg/liter had no effect on the action potential. It was concluded that antiarrhythmic effect of DuP 734 might depend on the decrease in the Ca2+ overload but not on K+ and Na+ channel blockade.

• Authors: Iu B Lishmanov, L N Maslov, A V Krylatov, S A Afanas'ev, V Iu Timofeev, P Gilligan, S V Tam
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2000 Nov-Dec Vol. 63 Issue 6 Pg. 24-7 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Issledovanie antiaritmicheskoĭ aktivnosti blokatora sigma-retseptorov DuP 734 v usloviiakh ishemii i reperfuzii miokarda.
• PMID: 11202505 (Publication Type: Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Narcotic Antagonists
• Piperidines
• Receptors, sigma
• DuP 734

Topics

• Action Potentials
• Animals
• Anti-Arrhythmia Agents (pharmacology)
• Arrhythmias, Cardiac (etiology, physiopathology, prevention & control)
• Arterial Occlusive Diseases (complications)
• Coronary Disease (complications)
• Electrocardiography
• In Vitro Techniques
• Microelectrodes
• Myocardial Infarction (etiology, pathology)
• Myocardial Reperfusion Injury (etiology, physiopathology, prevention & control)
• Myocardium (metabolism, pathology)
• Narcotic Antagonists (pharmacology)
• Piperidines (pharmacology)
• Rats
• Rats, Wistar
• Receptors, sigma (antagonists & inhibitors, metabolism)
• Sclerosis (prevention & control)