A clinical comparative study on effects of intracavernous injection of sodium nitroprusside and papaverine/phentolamine in erectile dysfunction patients.

Abstract

AIM:

To study the effect of intracavernous sodium nitroprusside (SNP), a nitric oxide (NO) donor, on penile erection.

METHODS:

Forty-two patients with erectile dysfunction (ED) were randomly assigned to receive SNP 300 micrograms or the control drugs (papaverine 30 mg + phentolamine 1 mg) intracavernously crosswise one week apart. The penile length, circumference and hardness after the administration of the experimental and control drugs were assessed and compared statistically.

RESULTS:

(1) There was no significant difference between the changes in penile length and circumference in the two occasions; (2) In 25 SNP and 28 control cases, the hardness of the penis was scored above 100 as evaluated by the Virag method (P > 0.05); (3) The duration of erection in the controls was longer than that in the SNP, but there were three priapism in the controls and not a single one in the SNP; (4) there was no apparent change in the heart rate and blood pressure in both occasions; other side effects were minimal except slight local pain in a few controls.

CONCLUSION:

SNP facilitates relaxation of the penile smooth muscle and penile erection without significant side effects. SNP may be used in ED patients that experience pain and priapism with papaverine/phentolamine.

• Authors: Q Fu, D H Yao, Y Q Jiang
• Journal: Asian journal of andrology (Asian J Androl) Vol. 2 Issue 4 Pg. 301-3 (Dec 2000) ISSN: 1008-682X [Print] China
• PMID: 11202421 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Nitric Oxide Donors
• Nitroprusside
• Nitric Oxide
• Papaverine
• Phentolamine

Topics

• Adult
• Aged
• Drug Administration Routes
• Drug Therapy, Combination
• Erectile Dysfunction (drug therapy, physiopathology)
• Humans
• Male
• Middle Aged
• Nitric Oxide (metabolism)
• Nitric Oxide Donors (administration & dosage, adverse effects)
• Nitroprusside (administration & dosage, adverse effects)
• Papaverine (administration & dosage, adverse effects)
• Penile Erection (drug effects, physiology)
• Penis (blood supply, drug effects, metabolism)
• Phentolamine (administration & dosage, adverse effects)