An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline.

Abstract

We assessed whether the efficacy of plant-source derived phosphatydilserine (one of the phospholipids which play an important functional role in membrane-related processes in the brain) for treatment of age related cognitive decline is consistent with previous (placebo controlled) positive findings with bovine derivative of PS (BC-PS). Eighteen healthy elderly volunteers meeting Age Associated Memory Impairment inclusion and exclusion criteria were treated for 12 weeks with plant-source derived phosphatydilserine (PS) (100 mg x 3/day p.o.) and evaluated at base line, after 6 weeks of treatment and at the end of the trial. Fifteen concluded the study. All but two outcome measures elicited a significant drug over time effect. Post-hoc paired t-tests showed that the significant effect was attributable to an improvement from base line to week 6 and that effect was maintained at week 12. These results are encouraging. However, they await double-blind controlled verification in a large sample before suggesting that this may be a viable approach to the treatment of age-related cognitive decline, without exposing the patients to possible hazards involved in the treatment with bovine derivative of PS (BC-PS).

• Authors: S Schreiber, O Kampf-Sherf, M Gorfine, D Kelly, Y Oppenheim, B Lerer
• Journal: The Israel journal of psychiatry and related sciences (Isr J Psychiatry Relat Sci) Vol. 37 Issue 4 Pg. 302-7 ( 2000) ISSN: 0333-7308 [Print] Israel
• PMID: 11201936 (Publication Type: Journal Article)

Chemical References

• Phosphatidylserines
• Plant Extracts

Topics

• Aged
• Alzheimer Disease (drug therapy)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Humans
• Neuropsychological Tests
• Phosphatidylserines (therapeutic use)
• Plant Extracts (therapeutic use)