[Survival of 2 years and 7 months with 5'-DFUR treatment in a patient with peritoneal gastric cancer recurrence].

Abstract

A 79-year-old male patient with peritoneal recurrence of gastric cancer 1 year and 7 months after radical operation was treated by oral administration of 5'-DFUR. After the beginning of oral administration of 5'-DFUR, he survived 2 years and 7 months with a good performance status and without any adverse effects. A very limited number of cases with long survival by the oral administration of 5'-DFUR after peritoneal recurrence of gastric cancer have been reported. Of a total of 653.0 g of 5'-DFUR administrated, 436.8 g (66.9%) were given in a protocol consisting of daily oral 1,600 mg of 5'-DFUR for 7 consecutive days and 7 drug free days. This high-dose (1,053 mg/m2/day) and intermittent method of 5'-DFUR administration might have contributed to the long survival and good performance status of this patient.

• Authors: Y Tamiya, M Oyamatu, Y Matubara
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 28 Issue 1 Pg. 91-4 (Jan 2001) ISSN: 0385-0684 [Print] Japan
• PMID: 11201388 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Floxuridine
• doxifluridine

Topics

• Aged
• Antimetabolites, Antineoplastic (administration & dosage)
• Drug Administration Schedule
• Floxuridine (administration & dosage)
• Humans
• Male
• Peritoneal Neoplasms (drug therapy, secondary)
• Stomach Neoplasms (pathology, surgery)
• Survivors