Abstract |
Partial deletion of the short arm of chromosome 4 (4p-) represents another (rare) cause of cleft lip and cleft palate. Further characteristic manifestations of the syndrome (also called Wolf or Wolf-Hirschhorn syndrome) are growth failure, microcephaly, prominent glabella, hypertelorism, beaked nose, poorly differentiated and low set ears, cardiac and renal malformation and hypospadias. Life expectancy is often shortened. The 4p- syndrome has many features in common with another deletion syndrome, the cri-du-chat syndrome, and also with the Smith-Lemli-Opitz syndrome. The latter is a hereditary condition with normal karyotype. The cri-du-chat syndrome is characterized by a peculiar high-pitched, mewing cry and can be differentiated from the Wolf syndrome by the different staining characteristics (banding) of chromosomes 4 and 5.
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Authors | H Zellweger, J Bardach, J Bordwell, K Williams |
Journal | Archives of otolaryngology (Chicago, Ill. : 1960)
(Arch Otolaryngol)
Vol. 101
Issue 1
Pg. 29-32
(Jan 1975)
ISSN: 0003-9977 [Print] United States |
PMID | 1119985
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Topics |
- Abnormalities, Multiple
(diagnosis)
- Chromosome Aberrations
(diagnosis)
- Chromosome Disorders
- Chromosomes, Human, 4-5
- Cleft Lip
(genetics)
- Cleft Palate
(genetics)
- Face
- Female
- Humans
- Infant, Newborn
- Karyotyping
- Syndrome
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