Abstract | OBJECTIVE: METHODS: RESULTS: After 6 months, healing was maintained (cumulative life table rates) in 93.6% (95% CI 87.4-99.7) of patients treated with esomeprazole 40 mg, 93.2% (95% CI 87.4-99.0) treated with esomeprazole 20 mg, and 57.1% (95% CI 45.2-69) treated with esomeprazole 10 mg; p < 0.001 vs placebo (29.1%; 95% CI 17.7-40.3). Of patients relapsing, mean time to first recurrence of esophagitis increased with dose, from 34 days (placebo) to 78 days (10 mg), 115 days (20 mg), and 163 days (40 mg). Patients treated with esomeprazole had less frequent and less severe heartburn than those treated with placebo. At month 6, more than 70% of patients being treated with esomeprazole remained symptom-free. CONCLUSIONS:
Esomeprazole is effective and well tolerated in the maintenance of a healing erosive esophagitis. Esomeprazole 40 mg and 20 mg maintain healing in over 90% of patients while providing effective control of heartburn symptoms.
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Authors | D A Johnson, S B Benjamin, N B Vakil, J L Goldstein, M Lamet, J Whipple, D Damico, B Hamelin |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 96
Issue 1
Pg. 27-34
(Jan 2001)
ISSN: 0002-9270 [Print] United States |
PMID | 11197282
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Enzyme Inhibitors
- Omeprazole
- Esomeprazole
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Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Biopsy, Needle
- Confidence Intervals
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Enzyme Inhibitors
(administration & dosage, adverse effects)
- Esomeprazole
- Esophagitis
(complications, drug therapy, pathology)
- Female
- Follow-Up Studies
- Gastric Mucosa
(drug effects, pathology)
- Gastroesophageal Reflux
(complications, diagnosis, drug therapy)
- Humans
- Male
- Middle Aged
- Omeprazole
(administration & dosage)
- Probability
- Reference Values
- Secondary Prevention
- Treatment Outcome
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