Abstract | AIM: METHODS: RESULTS: The mean PGF2alpha levels were 24.38 +/- 5.79 pg/ml in the control group and 10.99 +/- 4.11 pg/ml in the Latanoprost group, the difference of which was statistically significant (p < 0.05). In the Latanoprost group, there was a positive correlation between levels of PGF2alpha, and its metabolite (p < 0.05). CONCLUSION: Pretreatment with PGF2alpha isopropyl ester analogue, Latanoprost topically decreased PGF2alpha levels in the aqueous humor of glaucomatous eyes, probably due to its uveoscleral outflow increasing effect. The clinical importance and application of this result has to be determined.
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Authors | D Güven, A Karakurt, E Saban, H Hasiripi |
Journal | International ophthalmology
(Int Ophthalmol)
Vol. 23
Issue 2
Pg. 91-6
( 1999)
ISSN: 0165-5701 [Print] Netherlands |
PMID | 11196126
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Antihypertensive Agents
- Biomarkers
- Ophthalmic Solutions
- Prostaglandins F, Synthetic
- 15-keto-13,14-dihydroprostaglandin F2alpha
- Latanoprost
- Dinoprost
- Dinoprostone
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Topics |
- Aged
- Antihypertensive Agents
(administration & dosage, therapeutic use)
- Aqueous Humor
(drug effects, metabolism)
- Biomarkers
- Blood-Aqueous Barrier
(drug effects)
- Dinoprost
(analogs & derivatives, metabolism)
- Dinoprostone
(metabolism)
- Exfoliation Syndrome
(drug therapy, metabolism, surgery)
- Female
- Glaucoma, Open-Angle
(drug therapy, metabolism, surgery)
- Humans
- Immunoenzyme Techniques
- Intraocular Pressure
(drug effects)
- Latanoprost
- Male
- Ophthalmic Solutions
- Prostaglandins F, Synthetic
(administration & dosage, therapeutic use)
- Trabeculectomy
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