[Fluvoxamine (fevarin) in the treatment of depression].

Abstract

30 patients of 23-73 years old with endogenic and reactive depressions were treated with fevarin. The clinical state of the patients was estimated by means of Hamilton Depression Rating Scale (Ham-D). Fevarin was administrated in daily dose of 100-300 mg; the course of the treatment was equal to 4-8 weeks. The anxiolytic and antidepressive effects of fevarin were developed from the 5-7 days of the therapy: an anxiety disappeared completely by the end of the 3-d week. The most pronounced antidepressive effect was found for the classic depression with melancholy. A mild simulative effect and a normalization of a sleep were also observed. An improvement of the mental state was found in the all the patients by the end of the treatment: in 60% it was significant (a complete remission); in 40%--a considerable improvement was observed with the reduction of all clinical components of the depressive state. Fluvoxamine was found to be the high effective preparation for both endogenic and reactive depressions.

• Authors: M S Sheĭfer, M I Tsybina, M V Davydenko
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 100 Issue 12 Pg. 64-7 ( 2000) ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Fluvoksamin (fevarin) v terapii depressii.
• PMID: 11195542 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Antidepressive Agents, Second-Generation
• Fluvoxamine

Topics

• Adult
• Aged
• Antidepressive Agents, Second-Generation (administration & dosage, therapeutic use)
• Depressive Disorder (diagnosis, drug therapy)
• Drug Administration Schedule
• Female
• Fluvoxamine (administration & dosage, therapeutic use)
• Humans
• Male
• Middle Aged
• Severity of Illness Index
• Treatment Outcome