Oxidative stress leading to loss of critical proteases in Alzheimer's disease. An alternative view of the etiology of AD.

Abstract

An alternative view of the etiology of Alzheimer's disease is suggested which focuses on the relationship between oxidative stress and the decrease in proteases seen in aging. Proteases act to govern the acceleration of the pathology of aging and, as damage from oxidative stress increases, the loss of proteases in at-risk persons leads to symptoms of AD. Controlling the damage to proteases or controlling the generator(s) of oxidative stress may help to control the onset or progression of Alzheimer's disease.

• Authors: J M Carney
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 924 Pg. 160-3 ( 2000) ISSN: 0077-8923 [Print] United States
• PMID: 11193792 (Publication Type: Journal Article, Review)

Chemical References

• Endopeptidases

Topics

• Alzheimer Disease (etiology, metabolism)
• Brain (enzymology)
• Endopeptidases (metabolism)
• Humans
• Oxidative Stress (physiology)