An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin.

Abstract	We investigated the suppressive effects of an avocado constituent, persenone A, on lipopolysaccharide- and interferon-y-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in a mouse macrophage cell line RAW 264.7. Persenone A at concentration of 20 microM almost completely suppressed both iNOS and COX-2 protein expression. In mouse skin, double treatments with persenone A (810 nmol) significantly suppressed double 12-O-tetradecanoylphorbol-13-acetate (TPA, 8.1 nmol) application-induced hydrogen peroxide (H2O2) generation. Treatment with persenone A before the second TPA treatment was sufficient to inhibit H2O2 generation, while the first treatment was not. This study thus suggests that persenone A is a possible agent to prevent inflammation-associated diseases including cancer.
Authors	O K Kim, A Murakami, D Takahashi, Y Nakamura, K Torikai, H W Kim, H Ohigashi
Journal	Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 64 Issue 11 Pg. 2504-7 (Nov 2000) ISSN: 0916-8451 [Print] England
PMID	11193428 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Carcinogens Esters Fatty Alcohols persenone A Hydrogen Peroxide Nitric Oxide Synthase Nitric Oxide Synthase Type II Nos2 protein, mouse Prostaglandin-Endoperoxide Synthases Tetradecanoylphorbol Acetate
Topics	Animals Blotting, Western Carcinogens (toxicity) Enzyme Induction Esters (chemical synthesis, chemistry, pharmacology) Fatty Alcohols (chemical synthesis, chemistry, pharmacology) Female Gene Silencing (drug effects) Hydrogen Peroxide (metabolism) Lauraceae (chemistry) Macrophages (drug effects, enzymology) Mice Mice, Inbred ICR Nitric Oxide Synthase (genetics, metabolism) Nitric Oxide Synthase Type II Prostaglandin-Endoperoxide Synthases (genetics, metabolism) Skin (drug effects, metabolism) Tetradecanoylphorbol Acetate (toxicity)

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