Effect of liquid paraffin on antibody responses and local adverse reactions of bivalent oil adjuvanted vaccines containing newcastle disease virus and infectious bronchitis virus.

Abstract	Effects of liquid paraffin on antibody responses and local adverse reactions after intramuscular injection of oil adjuvanted vaccines containing Newcastle disease (ND) and infectious bronchitis (IB) virus were investigated in chickens. Each vaccine was prepared with a liquid paraffin such as Carnation, Crystol 52 and Lytol. These vaccines induced sustained antibody responses against ND and IB. Among local adverse reactions, Lytol induced granulomatous reactions and abscesses, but Carnation and Crystol 52 did not. The residual weight of liquid paraffin at the injection site decreased in the order Carnation, Crystol 52, Lytol. Crystol 52 was composed of relatively few short-chain hydrocarbons (i.e., <n-C16H34) and long-chain hydrocarbons (i.e., >n-C20H42). The vaccine with liquid paraffin mainly composed of n-C16H34-n-C20H42 was suggested to induce fewer adverse reactions.
Authors	S Fukanoki, K Matsumoto, H Mori, R Takeda
Journal	The Journal of veterinary medical science (J Vet Med Sci) Vol. 62 Issue 12 Pg. 1317-9 (Dec 2000) ISSN: 0916-7250 [Print] Japan
PMID	11193350 (Publication Type: Journal Article)
Chemical References	Adjuvants, Immunologic Antibodies, Viral Emulsions Viral Vaccines Mineral Oil
Topics	Adjuvants, Immunologic (administration & dosage, pharmacology) Animals Antibodies, Viral (biosynthesis, blood) Chickens Coronavirus Infections (immunology, prevention & control, veterinary) Emulsions Gas Chromatography-Mass Spectrometry (veterinary) Hemagglutination Inhibition Tests (veterinary) Infectious bronchitis virus (immunology) Injections, Intramuscular (veterinary) Mineral Oil (administration & dosage, chemistry) Neutralization Tests (veterinary) Newcastle Disease (immunology, prevention & control) Newcastle disease virus (immunology) Specific Pathogen-Free Organisms Vaccination (standards, veterinary) Viral Vaccines (administration & dosage, adverse effects, immunology)

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