Abstract |
Leukotrienes were found to be raised in respiratory syncytial virus bronchiolitis. Montelukast is a cysteinyl leukotrienes antagonist. We report our experience with the use of montelukast in three young children from 5-months to 20-months old. The first case was a 5-month-old boy with previous good health. He had prolonged respiratory distress secondary to adenovirus type 3 infection. The second case was a 20-month-old boy with bronchopulmonary dysplasia. He had respiratory syncytial virus and an adenovirus type 3 infection leading to prolonged wheeze. The third case was a 20-month-old girl with chronic lung disorder after an episode of severe E. coli pneumonia at 1 month old. She developed acute virus-negative severe wheeze after a few days of running nose and low-grade fever. All three cases responded poorly to inhaled steroids and bronchodilators. Addition of montelukast was associated with marked clinical improvement within 1 week. The three cases were very heterogeneous and differed from usual simple virus-induced acute bronchiolitis. The use of multiple drugs including montelukast did not enable any definite conclusions; however, the addition of montelukast was closely related to clinical improvement. Further studies in the use of montelukast in severe virus-induced bronchiolitis are warranted.
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Authors | D K Ng, A K Law, K W Chau, H K Chan |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 5
Issue 4
Pg. 389-92
(Dec 2000)
ISSN: 1323-7799 [Print] Australia |
PMID | 11192552
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Acetates
- Cyclopropanes
- Leukotriene Antagonists
- Leukotrienes
- Quinolines
- Sulfides
- montelukast
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Topics |
- Acetates
(pharmacology, therapeutic use)
- Acute Disease
- Age Factors
- Bronchiolitis, Viral
(drug therapy, immunology, microbiology, physiopathology)
- Cyclopropanes
- Female
- Humans
- Infant
- Leukotriene Antagonists
(pharmacology, therapeutic use)
- Leukotrienes
(immunology)
- Male
- Quinolines
(pharmacology, therapeutic use)
- Respiratory Sounds
(drug effects, immunology)
- Sulfides
- Treatment Outcome
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