Abstract |
Ferrimagnetic glass-ceramics were prepared as a heating mediator for hyperthermia in cancer treatment. We prepared glasses in the system 40Fe2O3-30CaO-30SiO2 and precipitated ferrimagnetic crystallites through controlled two-step heat treatment. To improve the heating capability of ferrimagnetic crystallites, i.e., magnetite, generation of other crystalline phases should be prohibited. The addition of each 1% of P2O5 and B2O3 led to lowering the crystallization temperature of magnetite, which was useful to suppress the other crystalline formation. The maximum nucleating and crystal growth rates were 20.47 x 10(6)/mm2 x s at 690 degrees C and 8.125 nm/min(0.5) at 940 degrees C, respectively. After nucleation at 690 degrees C for 60 min prior to crystal growth at 940 degrees C for 2 h, samples exhibited the following properties: crystallite size of 90.5 nm, the maximum volumetric fraction of 31.1%, and saturation magnetization of 100 emu/cm2. The coercive forces were ranged between 382.0 and 388.2 Oe in all heat-treatment conditions. As a result of a preclinical evaluation of biocompatibility by agar diffusion test with L929 cells, both as-quenched and heat-treated glasses could be biocompatible.
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Authors | S H Oh, S Y Choi, Y K Lee, K N Kim |
Journal | Journal of biomedical materials research
(J Biomed Mater Res)
Vol. 54
Issue 3
Pg. 360-5
(Mar 05 2001)
ISSN: 0021-9304 [Print] United States |
PMID | 11189041
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bone Substitutes
- Calcium Compounds
- Silicates
- calcium silicate
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Topics |
- Bone Substitutes
- Calcium Compounds
- Cell Survival
- Ceramics
(chemistry)
- Crystallization
- Differential Thermal Analysis
- Electromagnetic Fields
- Glass
(chemistry)
- Magnetics
- Microscopy, Electron
- Neoplasms
(therapy)
- Silicates
- Tumor Cells, Cultured
- X-Ray Diffraction
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