Abstract |
The authors experimented with a corticosteroid molecule, dexamethasone-isonicotinate, by pressurized aerosol, testing it on 15 subjects suffering from a bronchial obstructive syndrome (7 cases of asthmatic bronchitis, 6 of chronic bronchitis with pulmonary emphysema, 2 of bronchial asthma). In such patients clinical evolution, spirographic patterns, and airway resistance were studied by means of body plethysmograph before and after administration of 0.25 mg dexamethasone-isonicotinate four times a day. In four subjects daily variations of airway resistance before and after 10 days of treatment were evaluated: in three cases the resistance diminished noticeably at all times of the day after therapy. In eleven cases the functional parameters were recorded before and after 7 days therapy, and ten subjects were followed up by a monthly, check during 6 months of therapy. In both methods, the authors obtained good or very good results in more than half of the subjects and fair results in a fifth of the subjects; in the remaining patients poor results were obtained. Side-effects attributed to improper dosage were never observed.
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Authors | P Scotti, G Aresini |
Journal | Respiration; international review of thoracic diseases
(Respiration)
Vol. 32
Issue 3
Pg. 227-36
( 1975)
ISSN: 0025-7931 [Print] Switzerland |
PMID | 1118681
(Publication Type: Journal Article)
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Chemical References |
- Aerosols
- Isonicotinic Acids
- Dexamethasone
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Topics |
- Aerosols
- Airway Resistance
- Asthma
(drug therapy)
- Bronchitis
(drug therapy)
- Dexamethasone
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Humans
- Isonicotinic Acids
- Lung Diseases, Obstructive
(drug therapy, physiopathology)
- Pulmonary Emphysema
(drug therapy)
- Respiration
- Spirometry
- Vital Capacity
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