HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats.

Abstract
The effect of chronic exogenous testosterone (T) treatment on neuromuscular transmission in the diaphragm (Dia) muscle of adult male rats was determined. The contribution of neuromuscular transmission failure (NTF) to Dia fatigue was evaluated by superimposing intermittent direct muscle stimulation on repetitive nerve stimulation of isometric contraction in vitro. T treatment significantly reduced the contribution of NTF to Dia fatigue by approximately 20% (P < 0.001). Fiber type-specific effects on NTF were determined by measuring Dia fiber glycogen levels subsequent to repetitive nerve or muscle stimulation. T treatment had no effect on glycogen depletion in Dia type I and IIa fibers regardless of stimulation route. In the control group, type IIx fibers demonstrated significantly less glycogen depletion after nerve stimulation compared with direct muscle stimulation (P < 0.05), suggesting the presence of NTF. In contrast, T treatment increased glycogen depletion of type IIx fibers during nerve stimulation to levels similar to those after direct muscle stimulation. These data indicate that testosterone treatment substantially improves neuromuscular transmission in the Dia.
AuthorsC E Blanco, W Z Zhan, Y H Fang, G C Sieck
JournalJournal of applied physiology (Bethesda, Md. : 1985) (J Appl Physiol (1985)) Vol. 90 Issue 3 Pg. 850-6 (Mar 2001) ISSN: 8750-7587 [Print] United States
PMID11181592 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Drug Implants
  • Testosterone
  • Glycogen
Topics
  • Animals
  • Diaphragm (drug effects, innervation, physiology)
  • Drug Implants
  • Electric Stimulation
  • Glycogen (metabolism)
  • In Vitro Techniques
  • Isometric Contraction (drug effects, physiology)
  • Male
  • Muscle Fatigue
  • Muscle Fibers, Skeletal (physiology)
  • Muscle, Skeletal (drug effects, innervation, physiology)
  • Neuromuscular Junction (drug effects, physiology)
  • Rats
  • Rats, Sprague-Dawley
  • Synaptic Transmission (drug effects)
  • Testosterone (administration & dosage, pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: