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In vitro uptake of SCH 27899 (evernimicin) by rat alveolar macrophages.

Abstract
The in vitro uptake of [(14)C]evernimicin ([(14)C]SCH 27899) by primary cultures of rat alveolar macrophages and hepatocytes was determined. Both cell populations exhibited linear rates of uptake. However, the initial rate of drug uptake by alveolar macrophages was about threefold higher than that by hepatocytes. These findings demonstrate that [(14)C]evernimicin is taken up by rat alveolar macrophages, supporting the likelihood that the drug is able to reach sites of infection.
AuthorsS Zbaida, J Brieland, P Krieter, D Loebenberg, G Krishna, D Horne, X Lu, Y Yuan, R Hare, M N Cayen, J E Patrick
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 45 Issue 3 Pg. 959-61 (Mar 2001) ISSN: 0066-4804 [Print] United States
PMID11181391 (Publication Type: Journal Article)
Chemical References
  • Aminoglycosides
  • Anti-Bacterial Agents
  • Carbon Radioisotopes
  • Radiopharmaceuticals
  • evernimicin
Topics
  • Aminoglycosides
  • Animals
  • Anti-Bacterial Agents (chemistry, metabolism)
  • Biological Transport
  • Carbon Radioisotopes
  • Cells, Cultured
  • Hepatocytes (metabolism)
  • Macrophages, Alveolar (metabolism)
  • Radiopharmaceuticals (metabolism)
  • Rats

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