Endodermal sinus tumor: a report of two sustained remissions treated postoperatively with a combination of actinomycin D, 5-fluorouracil, and cyclophosphamide.

Abstract

The literature reflects a poor prognosis for women with endodermal sinus tumor. Two women with this neoplasm, 1 having stage IA and the other stage IIB disease were treated for 1 year postoperatively with a combination of actinomycin-D, 5-fluorouracil, and cyclophosphamide. Each had therapy discontinued after a negative second laparotomy and 15 and 21 months later are without recurrence. It is suggested that this drug regimen is a benficial adjunct to surgery in the treatment of endodermal sinus tumor.

• Authors: J P Forney, P J Di Saia, C P Morrow
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 45 Issue 2 Pg. 186-9 (Feb 1975) ISSN: 0029-7844 [Print] United States
• PMID: 1118091 (Publication Type: Journal Article)

Chemical References

• Dactinomycin
• Cyclophosphamide
• Fluorouracil

Topics

• Adolescent
• Adult
• Cyclophosphamide (administration & dosage, therapeutic use)
• Dactinomycin (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Female
• Fluorouracil (administration & dosage, therapeutic use)
• Humans
• Laparotomy
• Mesonephroma (drug therapy)
• Ovarian Neoplasms (drug therapy)
• Remission, Spontaneous
• Teratoma (drug therapy)
• Time Factors