From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited.

Abstract	The effect of French maritime pine bark extract (PBE) on the gene expression profile of HaCaT human keratinocytes was studied using high density filter arrays. The expression profile of both control and PBE-treated cells was determined. Interestingly, PBE was shown to downregulate both calgranulin A and B genes which are known to be upregulated in psoriasis and various dermatoses. Thus, PBE could be considered in human dermatoses.
Authors	B Rihn, C Saliou, M C Bottin, G Keith, L Packer
Journal	Phytotherapy research : PTR (Phytother Res) Vol. 15 Issue 1 Pg. 76-8 (Feb 2001) ISSN: 0951-418X [Print] England
PMID	11180529 (Publication Type: Journal Article)
Copyright	Copyright 2001 John Wiley & Sons, Ltd.
Chemical References	Flavonoids Plant Extracts pycnogenols
Topics	Cell Line (drug effects) Flavonoids (pharmacology, therapeutic use) Gene Expression Regulation Humans Keratinocytes (drug effects) Plant Extracts Plants, Medicinal Skin Diseases (drug therapy, genetics)

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