Biological activities of the plant-derived bisindole voacamine with reference to malaria.

Abstract

The in vivo antiplasmodial activity of voacamine was assessed in a 4-day test. It was shown to exhibit in vivo activity with 25.4% and 43.4% inhibition of parasitaemia with 2.5 and 10 mg/kg, respectively. In synchronized cultures, it was found to act on trophozoite and schizont stages of Plasmodium falciparum. Using the FMC29 strain of Plasmodium falciparum as parasite and the isobologram curve as a method to assess interaction in drug combination, it was shown to lack any chloroquine-enhancing activity and its in vitro antiplasmodial effect was not potentiated by the chemosensitizer malagashanine.

• Authors: D Ramanitrahasimbola, P Rasoanaivo, S Ratsimamanga-Urverg, E Federici, G Palazzino, C Galeffi, M Nicoletti
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 15 Issue 1 Pg. 30-3 (Feb 2001) ISSN: 0951-418X [Print] England
• PMID: 11180519 (Publication Type: Journal Article)
• Copyright: Copyright -Copyright 2001 John Wiley & Sons, Ltd.

Chemical References

• Alkaloids
• Antimalarials
• malagashanine
• voacamine
• Ibogaine
• Chloroquine

Topics

• Alkaloids (pharmacology)
• Animals
• Antimalarials (pharmacology)
• Chloroquine (pharmacology)
• Drug Synergism
• Ibogaine (analogs & derivatives, pharmacology)
• Mice
• Microbial Sensitivity Tests
• Plasmodium falciparum (drug effects)
• Plasmodium yoelii (drug effects)