Efficacy of ofloxacin and other otic preparations for otitis externa.

Abstract

Ofloxacin otic is as effective in curing otitis externa in children (<12 years of age) as is the preparation combining polymyxin/neomycin plus hydrocortisone and as ciprofloxacin otic. Furthermore ofloxacin otic, as it requires less frequent dosing, is likely to encourage greater patient adherence and consequently to achieve a better cure rate than both of these treatment options. Because a number of cases of otitis externa are complicated by an undiagnosed tympanic membrane perforation, the lack of ototoxicity associated with ofloxacin otic makes it a particularly safe option for use in these patients.

• Authors: R J Ruben
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 20 Issue 1 Pg. 108-10; discussion 120-2 (Jan 2001) ISSN: 0891-3668 [Print] United States
• PMID: 11176588 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Infective Agents
• Anti-Infective Agents, Local
• Ofloxacin

Topics

• Anti-Infective Agents (therapeutic use)
• Anti-Infective Agents, Local (therapeutic use)
• Bacteria (drug effects)
• Child
• Child, Preschool
• Humans
• Infant
• Middle Ear Ventilation
• Ofloxacin (therapeutic use)
• Otitis Externa (drug therapy, microbiology)
• Safety
• Treatment Outcome