Abstract |
The secretory immunoglobulin A ( sIgA) response at the intestinal mucosa is one of the primary defense mechanisms protecting against enteric infections and may therefore be used as an indicator of bacterial enteropathogenicity. In order to understand the role played by Aeromonas strains as gastrointestinal infectious agents, the sIgA response in fecal specimens obtained from patients with naturally acquired Aeromonas diarrhea was examined. Our results demonstrated a specific sIgA response which was directed against the exoproteins produced by Aeromonas strains. The specific Aeromonas sIgA reacted with extracellular products showing molecular masses similar to those of the Aeromonas hemolytic toxins such as aerolysin and AHH1. Some reactions were directed against other proteins that are known to be important factors in the pathogenicity of Aeromonas. The specific responses highlighted are in support of the view that one should consider at least certain biotypes of Aeromonas enteropathogenic.
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Authors | C Crivelli, A Demarta, R Peduzzi |
Journal | FEMS immunology and medical microbiology
(FEMS Immunol Med Microbiol)
Vol. 30
Issue 1
Pg. 31-5
(Feb 2001)
ISSN: 0928-8244 [Print] England |
PMID | 11172988
(Publication Type: Journal Article)
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Chemical References |
- Bacterial Proteins
- Immunoglobulin A, Secretory
- Lectins
- Plant Lectins
- jacalin
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Topics |
- Adult
- Aeromonas
(immunology)
- Aged
- Aged, 80 and over
- Bacterial Proteins
(metabolism)
- Blotting, Western
- Child, Preschool
- Diarrhea
(immunology, microbiology)
- Electrophoresis, Polyacrylamide Gel
- Feces
(microbiology)
- Female
- Gram-Negative Bacterial Infections
(immunology, microbiology)
- Humans
- Immunoglobulin A, Secretory
(analysis)
- Infant
- Lectins
- Male
- Middle Aged
- Plant Lectins
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