Abstract |
It is considered that nodosal ganglion grafting improves learning and memory disorder in nucleus basalis magnocellularis lesioned rats, and that [3H]- vesamicol is one of the mapping agents for presynaptic cholinergic neurons. Quantitative autoradiography was performed using high sensitive imaging plate system to evaluate the effect of neurotransplantation on [3H]- vesamicol binding. The affected-side to unaffected-side ratio of [3H]- vesamicol in the nucleus basalis magnocellularis lesioned group was significantly lower than that in the sham-operated group at 1, 2 and 4weeks (P<0.01). In the transplanted group, the ratio was significantly higher than that in the untreated group at 4weeks (P<0.05). [3H]- vesamicol binding is one of the most sensitive indicators of nucleus basalis magnocellularis lesions and the effect of the nodosal ganglion grafting.
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Authors | E Ikeda, A Ichikawa, H Mori, K Shiba, I Kuji, H Sumiya, N Tonami, K Ikeda |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 300
Issue 1
Pg. 33-6
(Mar 02 2001)
ISSN: 0304-3940 [Print] Ireland |
PMID | 11172933
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuromuscular Depolarizing Agents
- Piperidines
- vesamicol
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Topics |
- Animals
- Autoradiography
- Basal Nucleus of Meynert
(anatomy & histology, metabolism)
- Image Processing, Computer-Assisted
- Male
- Neuromuscular Depolarizing Agents
(metabolism)
- Piperidines
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Transplantation, Autologous
(physiology)
- Vagus Nerve
(transplantation)
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